Science

Unknown Antigen

Problem: Discovery of disease-specific pathogenic antigens is difficult, if not impossible, using conventional methods.  Consequently definitive immuno-therapeutic targets are severely limited and extremely expensive.

 
“Proxy Antigens” Identify Definitive Therapeutic Targets

Immune system responds to pathogenic antigens.

Immune system responds to pathogenic antigens.

Proxy antigen bind to specific antibodies in blood.

Proxy antigens bind to specific antibodies in blood.

Proxy antigen libraries (>1012) isolate disease-specific antibodies.Proxy antigen libraries (>1012) isolate disease-specific antibodies.

Disease-specific antibodies isolate target antigens& gene ID.

Disease-specific antibodies isolate target antigens & gene ID.

Leverages the Immune System

  1. Immune response generates and amplifies antibodies at onset of molecular pathogenesis.
  2. Proxy antigens measure the disease-specific antibodies retained in blood.